Progress in the research of insulin-like growth factor family in lung cancer
10.3781/j.issn.1000-7431.2010.04.018
- VernacularTitle:胰岛素样生长因子家族在肺癌中的研究进展
- Author:
Liangkun YOU
;
Yongde LIAO
;
Shengling FU
;
Sheng JU
;
Guang CHEN
;
Xin XING
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Somatomedins;
Receptors,somatomedin;
Insulin-like growth factor binding proteins
- From:
Tumor
2010;(4):356-360
- CountryChina
- Language:Chinese
-
Abstract:
Insulin-like growth factors (IGF), regulated by their receptors and binding proteins, play a pivotal role in human cell proliferation, differentiation and apoptosis. Increasing evidence has revealed that IGF system is involved in the genesis and progress of various malignancies including lung cancer. Recent studies in regard to IGF axis expression in the lung cancer cell lines, pulmonary tissue samples and blood circulation of lung cancer patients have shown that the IGF axis may contribute to the transformation and progression of lung cancer. Several researches have shown that a number of drugs targeting the IGF receptor are being investigated in clinical trials and suggest a potential therapeutic efficacy. This article reviews the updates and progress in the research of IGF axis in lung cancer.
