PI3K/Akt signaling pathway and neuroprotection
10.3760/cma.j.issn.1673-4165.2013.02.013
- VernacularTitle:PI3K/Akt信号通路与神经保护
- Author:
Fan YANG
;
Qiquan ZHOU
- Publication Type:Journal Article
- Keywords:
Phosphatidylinositol 3-Kinases;
Proto-Oncogene Proteins c-akt;
Brain Ischemia;
Blood-Brain Barrier;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2013;(2):143-147
- CountryChina
- Language:Chinese
-
Abstract:
PI3K/Akt pathway is a biological signal transduction pathway activated by phosphatidylinositol 3-kinase (PI3K).It plays a key role in cell proliferation,cell-cycle regulation,apoptosis initiation,and angiogenesis.In addition,the PI3K/Akt pathway is closely associated with the protection mechanisms of central nervous system damage.In-depth study of PI3K/Akt,downstream molecules and their regulation mechanisms,can provide some new ideas and methods for the treatment of brain injury.
