Irisin: a new hope for type 2 diabetes and obesity
10.3760/cma.j.issn.1000-6699.2013.01.002
- VernacularTitle:2型糖尿病和肥胖的新希望:Irisin
- Author:
Shuhang XU
;
Dengyue ZHU
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
Irisin;
Exercise;
Diabetes mellitus,type 2;
Obesity
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(1):7-8
- CountryChina
- Language:Chinese
-
Abstract:
The mechanisms underlying the therapeutic effects of exercise on obesity and type 2 diabetes remained unknown until irisin,a novel hormone secreted from muscle tissue,was identified.Irisin increases total energy expenditure,reduces body weight,and mitigates diet-induced insulin resistance,thus improving glycemic control.Interestingly,the concentration of irisin increases significantly after endurance exercise,suggesting there is an association between exercise and metabolism.Given its antiobesity and antidiabetic effects,irisin has been postulated to serve as an injectable treatment for metabolic disease including obesity and type 2 diabetes.
