Changes of muscle induced with injection of botulinum toxin type A in different period of time

VernacularTitle:A型肉毒毒素肌内注射后不同时间段肌肉改变的观察
Author: Hao WANG ; Senkai LI ; Mingyong YANG ; Yangqun LI ; Qiang LI ; Yining WANG ; Shiwei BAO
Publication Type:Journal Article
Keywords: Botulinum toxin A; Muscle; Metabolism
From:Chinese Journal of Medical Aesthetics and Cosmetology 2012;(6):444-446
CountryChina
Language:Chinese
Abstract: Objective To study the changes of muscle being injected with botulinum toxin A in different period of time,helping for chemically denervated muscle transplantation.Methods Sixteen rabbits were divided into 4 groups.The extensor carpi radialis muscle in one side was chosen for experimental group with the opposite muscle for control group.Morphological changes,histological changes and electron microscopic changes of muscle being injected with botulinum toxin A were observed from the first week to the fouth week.Results The quantity of glycogen and mitochondria in the muscles reduced in the first week.But it was obvious in the third week.We also found some necrotic areas in the fouth week with the muscles restoring.Conclusions The effect of metabolism slowing down and the volume of muscle reducing after botulinum toxin A injection is obvious in third weeks.It could help us choose the best time of chemically denervated muscle transplantation.