Sirt1:A novel target for treatment in cardiovascular diseases
10.3760/cma.j.issn.1673-4408.2012.06.017
- VernacularTitle:Sir1:心血管疾病药物治疗的潜在靶点
- Author:
Jun XIE
- Publication Type:Journal Article
- Keywords:
Histone deacetylase;
Sirt1;
Cardiovascular diseases
- From:
International Journal of Pediatrics
2012;(6):598-601
- CountryChina
- Language:Chinese
-
Abstract:
Silence information regulator factor 1 (Sirt1) has been demonstrated to be a multi-functional regulator act as a deacetylase.It regulates in critical pathophysiologic pathways,including gene transcription,energy metabolism and senescence.It has been shown that Sirtl regulates the growth and development of myocardial tissue and the formation of blood vessels,also modulates the energy metabolism and oxidative stress of cardiovascular system and so forth.The transcriptional regulator may play a potential role in clinical application and research of cardiovascular diseases.
