Expression and significance of telomerase in development process of scar formation
10.3760/cma.j.issn.1671-0290.2012.02.014
- VernacularTitle:端粒酶在瘢痕发生发展过程中的表达及意义
- Author:
Lei CHEN
;
Ruixia KUANG
;
Jing FANG
;
Wenjun ZHAO
;
Huichao LI
- Publication Type:Journal Article
- Keywords:
Telomerase;
Granulation tissue;
Keloid;
Mature scar;
Hypertrophic scar
- From:Chinese Journal of Medical Aesthetics and Cosmetology
2012;18(2):128-131
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression of telomerase of fibroblasts in the formation and development of scar,and to investgate the relationship between the telomerase activity and the formation and development of scar.MethodsExpression of telomerase was detected by immunohistochemical techniques in 18 specimens from granulation tissue,17 keloid,16 specimens from hypertrophic scar,28 specimens from mature scar,32 specimens from normal skin,and SPSS16.0 statistics software was used to analyze the relationship between telomerase and scar.Results It was shown that the positive expression rate of telomerase in the granulation tissue group was 94.4 ％,that in the keloid group was 58.8 ％,that in the hypertrophic scar group was 18.8 ％, and that in the mature scar and in the normal skin was zero. comparisons between groups,in addition to the normal scar group and normal skin group,other groups were statistically significant differences.ConclnsionsScar formation is a process with multi-factor participation,while telomerase activation is an important factor. Detecting telomerase activity in the development process of scar formation may determine the prognosis.Through the control of telomerase activity in the pathogenesis of scar may become a new approach of scar treatment.
