Comparing studies of silybin metabolism in normal rats and liver injury model rats
10.3760/cma.j.issn.1673-4246.2012.08.009
- VernacularTitle:水飞蓟宾在正常大鼠和肝损伤模型大鼠体内代谢的比较研究
- Author:
Yang LIU
;
Shuofeng ZHANG
;
Wenning YANG
;
Guoqing OUYANG
;
Xiaoyan GAO
;
Baosheng ZHAO
;
Honghuan DONG
;
Lei ZHANG
;
Liying LIU
- Publication Type:Journal Article
- Keywords:
Silybin;
Normal rats;
Model rats;
Metabolism;
Distribution
- From:International Journal of Traditional Chinese Medicine
2012;34(8):700-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the metabolism and distribution ofsilybin in normal rats and liver injury model rats.Methods The normal rats group and immunity liver injury rat models were fed with the same dose ofsilybin capsule,and HPLC was used to determine the silybin concentration in biological samples in different time.Results The silybin concentration in the normal group in biological samples was higher than the model group at different time.In the normal group,the consequence of silybin concentration in each viscera distribution from top to bottom was liver＞kidneys＞plasma＞heart,while in the model group the fact was kidneys＞heart＞liver＞plasma.Conclusion The difference of metabolism and distribution of silybin in normal rats and liver damage model rats was obvious.
