Protective effects of terlipressin on renal function of recipients after liver transplantation
10.3760/cma.j.issn.0254-1785.2012.08.012
- VernacularTitle:特利加压素对肝移植受者肾功能的影响
- Author:
Kunkun XIA
;
Shuijun ZHANG
;
Yang WU
;
Wenzhi GUO
;
Zhe TANG
;
Yongfu ZHAO
;
Rongqing SUN
- Publication Type:Journal Article
- Keywords:
Terlipressin;
Liver transplantation;
Kidney failure
- From:
Chinese Journal of Organ Transplantation
2012;33(8):488-490
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the protective effects of terlipressin on the renal function of recipients afterlivertransplantation.MethodsAmong 35casesreceivingorthotopicliver transplantation (OLT),16 cases were given terlipressin (group T):continuous infusion of terlipressin (1mg) into the vein immediately after the operation,twice every day for 3-4 days;19 cases were given dopamine and procaine (group D):continuous infusion of dopamine (40 mg) and procaine (0.5 g) into the vein immediately after the operation,twice every day for 3-5 days.In both two groups,the serum creatinine and urea nitrogen levels were normal before the operation. Serum creatinine,urea nitrogen,serum β2 microglobulin and urine amount were determined.ResultsSerum creatinine,urea nitrogen,serum β2 microglobulin and urine amount were increased significantly at 5th day after operation in both two groups (P＜0.05).As compared with group D,urea nitrogen and serum β2 microglobulin were decreased,while the urine amount increased significantly at 5th day after operation in group D (P＜0.05).Three cases (18.8％) in group T,and10 cases (52.6％ ) in group D developed RFALT at 5th day after operation (P＜0.05).ConclusionTerlipressin can protect the renal function of recipients after liver transplantation,and it can more effectively provide good recovery conditions for the recipients who develop RFALT after liver transplantation.
