To explore the serum level of transforming growth factor-β1 ( TGF-β1 ) in patients with prehypertension and impaired fasting blood glucose
10.3760/cma.j.issn.1008-1372.2012.07.010
- VernacularTitle:正常高值血压合并空腹血糖受损患者血清转化生长因子β1水平的探讨
- Author:
Juanjuan ZHANG
;
Fuye ZHANG
;
Feng YUE
;
Guiying LI
;
Kun ZHANG
- Publication Type:Journal Article
- Keywords:
Prehypertension/complications/metabolism;
Glucose intolerance;
Blood glucose/metabolism;
Transforming growth factor beta1/blood
- From:
Journal of Chinese Physician
2012;14(7):895-897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the level of serum transforming growth factor-β1 (TGF-β1) in patients with prehypertension and impaired fasting blood glucose.Methods A total of 180 healthy subjects with matched age and sex was divided into 3 groups:group A (blood pressure ＜ 120/80 mmHg and fasting blood glucose ＜6.1 mmoVL),group B (prehypertension and fasting blood glucose ＜6.1 mmol/L),group C (prehypertension and 6.1 mmol/L≤ fasting blood glucose ≤7.0 mmol/L).There were 60 subjects in every group.Serum TGF-β1 was measured by Enzyme-Linked Immunosobent Assay (ELISA),fasting blood glucose,triglyceride,total cholesterol,low-density lipoprotein cholesterol ( LDL-C),high-density lipoprotein cholesterol ( HDL-C),Uric Acid ( UA),body mass index (BMI) were determined.Results The level of serum TGF-β1 in group B and C was higher in that in group A( t =2.071,and 2.147,P ＜0.05 ).The level of serum TGF-β1 was higher in group C than group B,but no significant difference was observed ( P ＞0.05).The pearson correlation analysis showed there was a significant correlation between TGF-β1 and systolic blood pressure ( r =0.279,P =0.047).Conclusions The level of serum TGF-β1 was higher in patients with prehypertention which may mediate the target organ damage caused by the prehypertention.
