Risk factors of decreased glomerular filtration rate in patients with primary aldosteronism

VernacularTitle:影响原发性醛固酮增多症患者肾小球滤过率相关因素分析
Author: Jian ZENG ; Nanfang LI ; Xinling WANG ; Feiya ZU ; Delian ZHANG ; Guijuan CHANG ; Keming ZHOU
Publication Type:Journal Article
Keywords: Hyperaldosteronism; Glomerular filtration rate
From: Chinese Journal of General Practitioners 2012;11(2):141-143
CountryChina
Language:Chinese
Abstract: One hundred and fifty-six patients with primary aldosteronism(PA)and 189 patients with essential hypertension (EH) were included in this study.The value of estimate glomerular filtration rate (eGFR) was calculated by MDRD equation.The plasma levels of aldosterone,triglycerides,creatinine and fasting glucose were measured.The plasma creatine,24 hour urine albumin excretion in PA patients were higher and eGFR and plasma aldosterone were lower than those in EH patients ( all P ＜ 0.01 ).Multiple regression analysis revealed that the plasma concentrations of aldosterone ( P =0.003 ) and creatinine ( P =0.001 ) were independent predictors of eGFR.