β-cell function of subjects with 1-hour hyperglycemia in oral glucose tolerance test

VernacularTitle:口服葡萄糖耐量试验1h血糖升高体检者胰岛β细胞功能的观察
Author: Jing GUAN ; Ying YANG ; Xiancheng LIU ; Caixia HE ; Xiaohua JIN
Publication Type:Journal Article
Keywords: Glucose metabolism disorders; pancreatic β-cell function
From:Chinese Journal of General Practitioners 2011;10(11):827-829
CountryChina
Language:Chinese
Abstract: Based on the results of oral glucose tolerance test( OGTT )and the levels of 1-h plasma glucose ( 1 hPG),793 subjects were classified into three groups:583 with NGTN ( normal 1 hPG in OGTT),127 with NGT1 H( higher 1 hPG in OGTT) and 83 with IGT( impaired glucose tolerance).NGT1H group had large waist circumference,higher body mass index,fasting plasma glucose( FPG),triglyceride,and lower high density lipoprotein-cholesterol than those of NGTN group.NGT1 H group had higher homeostasis model assessment insulin index ( 1.2 ± 0.6),lower homeostasis model assessment β3 ( HOMA-β ) (4.5 ± 0.7 ) and insulinogenic index (2.1 ±0.7) than those of NGTN group(0.5 ±0.6,4.8 ±0.7,2.7 ±0.9,respectively,all P ＜0.05 ).HOMA-β of NGT1 H group was higher than that of IGT group(4.5 ±0.7 vs.4.4 ±0.6,P ＜0.05 ).The results indicate that 1 hPG in OGTT may identify a condition of glucose metabolic abnormalities characterized by insulin resistance and reduced β-cell function.