Utility of fluorescence in situ hybridization urine test for the diagnosis of upper urinary tract urothelial carcinoma
10.3760/cma.j.issn.1000-6702.2011.10.004
- VernacularTitle:荧光原位杂交技术尿脱落细胞检测在上尿路尿路上皮细胞癌诊断中的应用价值
- Author:
Baoli HU
;
Zhankui JIA
;
Jinjian YANG
;
Ruiting CHEN
;
Lan ZHANG
- Publication Type:Journal Article
- Keywords:
Fluorescence in situ hybridization;
Urothelial;
Tumor markers,biological
- From:
Chinese Journal of Urology
2011;32(10):659-661
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical utility of fluorescence in situ hybridization (FISH) urine test as a non-invasive method for diagnosing the upper urinary tract urothelial carcinoma (UUTUC).Methods Urine specimens from 30 consecutive patients with UUTUC were analyzed by means of FISH and cytology.Ultrasonic and CT were also used to analyze urine specimens from the study group.Urine specimens from 30 patients with other diseases were also analyzed by means of FISH and cytology in order to compare the specificity.Results The sensitivities of FISH,cytology,CT and ultrasonic were 87％,37％,90％ and 43％.The specificity of FISH and cytology were 97％ and 93％.The sensitivity between FISH and MMCT were compared and they were not statistically significantly superior to ultrasonic and cytology.FISH and cytology were compared and no specific statistical significance was found.The positive and negative predictive value for FISH was 96％ and 88％.For cytology it was 85％ and 60％.Conclusions FISH analysis is a useful ancillary test in the detection of UT-TCC with excellent sensitivity and specificity.It provides a more reliable and less invasive approach to diagnosis and postoperative follow-up for UT-TCC.
