SIRT1 and neoplasms
10.3760/cma.j.issn.1673-422X.2011.08.003
- VernacularTitle:SIRT1与肿瘤
- Author:
Shuqin GUO
;
Chunying ZHU
;
Yunliang ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
SIRT1
- From:
Journal of International Oncology
2011;38(8):569-572
- CountryChina
- Language:Chinese
-
Abstract:
SIRT1 (Sirtuin type 1 ), a member of histone deacetylase, dependents on nicotinamide adenine dinucleotide ( NAD + ). It involves in the covalent modification of histones, participates in tumor development and progression through transcription, translation and post-translational modification and so on. Therefore, the expression of SIRT1 in tumor cells or abnormal function could be one of the important mechanisms of tumor development, and may become a new potential therapeutic target for neoplasms.
