Clinical analysis of 330 patients with primry aldosteronism

VernacularTitle:330例原发性醛固酮增多症患者的临床分析
Author: Nanfang LI ; Hongjian LI ; Hongmei WANG ; Xinling WANG ; Feiya ZU ; Guijuan CHANG ; Keming ZHOU ; Qin LUO ; Menghui WANG ; Junli HU ; Lei WANG
Publication Type:Journal Article
Keywords: Primary aldosteronism; Aldosterone; Renin activity; Aldosterone-to-rennin activity ratio
From: Chinese Journal of Endocrinology and Metabolism 2011;27(9):752-754
CountryChina
Language:Chinese
Abstract: The clinical data of 330 patients with primary aldosteronism (PA) from January 2006 to March 2010 were retrospectively analyzed. The prevalence of 1, 2, and 3 stage hypertension in these subjects was 3.64％,20. 91％, and 75.45 ％, respectively. Of all PA patients, 89.09％ were young adults and 81.82％ were overweight or obese. There was a marked preponderance of male patients in the overweight or obese group ( P＜0. 01 ). The incidence of hypokalemia was 32. 12％. The concentration of serum potassium was not associated with the disease course. Logistic regression showed that the concentration of plasma aldosterone was an independent risk factor of hypokalemia in PA patients( P＜0. 01 ). 79. 09％ PA patients presented the plasma aldosterone level over 12 ng/dl and the renin activity level of less than 1 ng · ml-1 · h-1. The aldosterone-to-rennin activity ratio was ＞20 in 94.24％ of the patients with PA.