Association of obesity and hyperandrogenemia with insulin resistance in women with polycystic ovary syndrome
10.3760/cma.j.issn.1000-6699.2011.09.007
- VernacularTitle:多囊卵巢综合征患者肥胖和高雄激素血症与胰岛素抵抗的相关性
- Author:
Jin LI
;
Cheng XU
;
Huijie ZHANG
;
Ji HONG
;
Guang NING
;
Xiaoying LI
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Insulin resistance;
Obesity;
Hyperandrogenemia
- From:Chinese Journal of Endocrinology and Metabolism
2011;27(9):733-735
- CountryChina
- Language:Chinese
-
Abstract:
Thirty healthy women and 101 patients with polycystic ovary syndrome (PCOS) were recruited. According to serum testosterone (T) level and homeostasis model assessment for insulin resistance (HOMA-IR) ,the correlation of T and body mass index (BMI) with insulin resistance was analyzed. The results showed that there were 39. 8％ normal,24. 5％ overweight,and 35.7％ obese among 101 PCOS patients. However,there were no significantly differences in BMI, fasting plasma glucose ( FPG ), triglyceride ( TG ), total cholesterol ( TC), low-density lipoprotein-cholesterol ( LDL-C), high-density lipoprotein-cholesterol ( HDL-C ), and HOMA-IR levels between PCOS patients with hyperandrogenemia ( T ≥ 0. 51 μg/L) and normal androgenemia ( T ＜ 0. 51 μg/L). BMI, FPG, TG, TC, and LDL-C levels were higher and HDL-C level was lower in patients with insulin resistance( HOMA-IR ≥ 2. 29 ) than in patients without insulin resistance ( HOMA-IR ＜ 2. 29, P＜0. 05 or P＜ 0. 01 ). Serum T levels were not significantly different between two groups. HOMA-IR was significantly correlated with BMI(P＜0. 01 ), not with serum T, suggesting that the gain of body weight is correlated with insulin resistance independent of serum T level.
