Heterogeneous dermal acellular matrix graft for clinical urethroplasty
10.3760/cma.j.issn.1000-6702.2012.02.019
- VernacularTitle:异种真皮去细胞基质在尿道重建中的临床应用
- Author:
Jian LIN
;
Minghua ZHANG
;
Cheng CHEN
;
Jie JIN
;
Liqun ZHOU
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Heterogeneous;
Acellular matrix graft;
Urethral stricture;
Urethroplasty
- From:
Chinese Journal of Urology
2012;33(2):143-145
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical safety and validity of heterogeneous dermal acellular matrix graft (ACMG) for urethral reconstruction in patients.Methods Ten male patients aged 36( range,20 - 62),stricture length 6.9 cm ( range,3.0 - 15.0 cm),were treated with the ACMG material.During the operation,ACMG was sutured to a tubular graft or as a patch and replaced the defect urethra.Urinary catheter was inserted in the reconstructed urethra for 6 months.Then the outcomes of this operation method and whether there were rejections against the material were observed.Results All 10 patients could void through normal urethral,and no rejection was observed.Retrograde urethral visualization and urethroscope gave evidences of smooth urethral and continuous mucosa.The patients were followed up for 18months,and all patients voided normally except 2 cases needed urethral dilatation.ConclusionsHeterogeneous dermal ACMG for urethroplasty in men has the excellence of good biocompatibility,constructing the functional urethra.Additionally,this material could be manufactured with greater scale and advanced technology,which made it appropriate for operation of harder and longer urethral stricture diseases,serving as an ideal replacement material of urethra.
