Neuroprotective effect of peroxisome proliferator-activated receptor γ coactivator-1α in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2012.08.015
- VernacularTitle:过氧化物酶体增殖物激活受体γ辅助活化因子-1α在脑缺血中的神经保护作用
- Author:
Yong HAN
;
Dujuan SHA
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
PPARGC1A Protein;
Peroxisome-Proliferator-Activated Receptor-γCoactivator-1;
Brain Ischemia;
Transcription Factors;
Neuroprotective Angents
- From:International Journal of Cerebrovascular Diseases
2012;20(8):631-636
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferative-activated receptor (PPAR) γ coactivator-1α (PGC-1α) is a transcriptional coactivator of PPARγ.PGC-1α can bind with many different transcription factors.It plays a number of functions in the different tissues and the process of biological reaction.Recent studies have shown that PGC-1α signaling pathway has a neuroprotective effect.This article reviews the neuroprotective effect of PGC-1α in cerebral ischernia and its possible mechanisms.
