Myostatin mRNA expression in patients of Duchenne muscular dystrophy
10.3760/cma.j.issn.1006-7876.2011.11.007
- VernacularTitle:Duchenne型肌营养不良患者肌肉组织myostatin mRNA的表达
- Author:
Xiaoping ZHAO
;
Chuanqiang PU
;
Yanling MAO
;
Jiexiao LIU
- Publication Type:Journal Article
- Keywords:
Muscular dystrophy,duchenne;
Myostatin;
RNA,Messenger
- From:Chinese Journal of Neurology
2011;44(11):750-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of myostatin mRNA,a negative regulator of muscle growth,in the skeletal muscle of Duchenne muscular dystrophy(DMD)patients.Methods A semi-quantitative reverse transcription polymerase chain reaction was performed to evaluate the expression of myostatin in the skeletal muscle of 7 DMD patients and 4 healthy controls.Results The level of myostatin gene expression in the skeletal muscle of DMD patients was higher than that of healthy controls(0.56 ± 0.16 vs 0.34 ± 0.15,Z =-2.268,P =0.023).Conclusions The myostatin gene expression was increased in the DMD patients compared to the healthy controls.Enhanced expression of myostatin in the skeletal muscle might be involved in the pathogenesis of DMD.
