Expression and significance of vasculogenic mimicry and matrix metalloproteinase-2 in prostate cancer
10.3760/cma.j.issn.1000-6702.2012.10.021
- VernacularTitle:血管生成拟态和基质金属蛋白酶-2在前列腺癌中的表达及意义
- Author:
Kuo YANG
;
Chao MENG
;
Yong XU
;
Yan LIU
;
Zhihong ZHANG
;
Ranlu LIU
;
Baojie MA
- Publication Type:Journal Article
- Keywords:
Prostate cancer;
Vasculogenic mimicry;
MMP-2;
Prognosis
- From:
Chinese Journal of Urology
2012;33(10):791-794
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out if an unique blood mode-vasculogenic mimicry (VM) exist in prostate cancer and analyze its relationship with prognosis. Methods The age of the patients was 59 to 72 years,with a mean age of (66.7 ± 11.0) years.All had been confirmed as prostate cancer by biopsy.The level of serum PSA was 15.6 to 76.7 μg/L,with a mean level of (34.6 ± 1.7 ) μg/L.A histochemical and immunohistochemical dual staining method for PAS-CD31 and MMP-2 in 96 prostatic adenocarcinomas were conducted to explore if VM exist in prostate cancer,describe its morphology and distribution.The different expression of MMP-2 in VM positive and VM negative tissue were.The clinical data were collected and analyzed to explore the relationship between disease progression and VM. Results Among 96 cases,24 cases were found VM positive,the others were negative.The boundary membrane of VM was PAS positive,which was continuous or incontinuous. A positive correlation between VM density and high Gleason score were found.The tPSA were higher in the VM positive cases than that in VM negatives.The VM positive patients had poorer prognosis than that of the negatives.The MMP-2 expression was found correlated with VM positive (rs =0.60,P ＜ 0.01 ). Conclusions VM exists in the prostate cancer as an independent structure,and it is more common in the high-grade cancer.The progression-free survival of VM positive patients could be worse than the negative.MMP-2 and VM could be the indicators of poor prognosis.
