A correlation study between ITGA6 gene, chromosome 8q24, MSMB genes and prostate cancer
10.3760/cma.j.issn.1000-6702.2011.07.010
- VernacularTitle:整合素α6、β-微精浆蛋白基因和染色体8q24区与前列腺癌的关联研究
- Author:
Jianye WANG
;
Ze YANG
;
Dong WEI
;
Xiaohong SHI
;
Yaoguang ZHANG
;
Ming LIU
;
Xin WANG
;
Changhu ZHOU
;
Xin CHEN
;
Jin HUANG
;
Yige YANG
- Publication Type:Journal Article
- Keywords:
ITGA6 gene;
Chromosome 8q24;
MSMB gene;
Prostatic neoplasms;
Association
- From:
Chinese Journal of Urology
2011;32(7):471-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between ITGA6 gene (rs12621278, G), MSMB gene (rs10993994, T), chromosome 8q24 (rs10086908, T) and prostate cancer (PCa) in Beijing residents, and to explore the correlation between genotype and phenotype in PCa patients. Methods PCa patient phenotypes were collected including clinical, genetic, dietary habits, hobbies and blood samples. ITGA6 gene (rs12621278, G), chromosome 8q24 (rs10086908, T) and MSMB gene (rs10993994, T) compared the allele distribution between 112 PCa and 91 healthy control age matched patients. The genotype and phenotype analysis was conducted in the 2 groups. Results Between the case and control groups, only rs10993994, T of MSMB gene (case 56.4%,control 46.2%) was significantly different (P=0.001; OR=1.97, 95%CI:1.28-3.04). The rs10086908, T of 8q24 (case 83.5%, control 79.2%) and rs12621278, G of ITGA6 gene (case 27.2%, control 27.0%) were not significantly associated with PCa in the study sample (P>0.05). Quantitative trait analysis showed that the disease duration of ITGA6 risk genotypes (G/G,1.40±0.55 years) in PCa patients was significantly shorter (P=0.003) than the other genotype carriers (A/G, 4.38±3.10 years; A/A, 2.37±1.84 years). Conclusion The genetic variation in MSMB is possibly associated with PCa susceptibility, suggesting that MSMB genes might be associated with PCa in a Chinese population.