Role of G-protein-coupled receptor kinases in cell migration and signal transduction
10.3969/j.issn.1000-4718.2011.07.036
- VernacularTitle:G蛋白偶联受体激酶在细胞迁移和细胞信号转导中的作用
- Author:
Xin CAI
;
Jing CHEN
;
Jingmei ZHANG
;
Bo BAI
- Publication Type:Journal Article
- Keywords:
G-protein-coupled receptors kinases;
Receptors,G-protein-coupled;
Signal transduction
- From:
Chinese Journal of Pathophysiology
2011;27(7):1438-1444
- CountryChina
- Language:Chinese
-
Abstract:
G-protein-coupled receptor kinases (GRKs) are a family of serine/threonine protein kinases. The investigators pay much attention to the roles of GRKs in the signal transduction through G-protein-coupled receptors (GPCRs) with arrestin ever since a long time ago. Due to the physiological and pathological observations with the methods of deletion or overexpression, GRKs are considered as new drug targets. The kinases play a role in the pathogenesis of hypertension and cell migration through GPCRs and Hedgehog signaling pathways. As the development of research techniques, especially bioluminescence resonance energy transfer (BRET) and fluorescence resonance energy transfer (FRET), the special mechanism of GRKs for GPCRs is more evident. In this review, we discuss the recent achievement in the roles of GRKs signaling and the related newest research techniques.
