Effect of X-rays on the expression of B7-1 and B7-2 in per itoneal macrophages
- VernacularTitle:X射线对小鼠腹腔巨噬细胞表达B7-1和B7-2的影响
- Author:
Shunzi JIN
;
Shuzheng LIU
- Publication Type:Journal Article
- From:Journal of Jilin University(Medicine Edition)
2001;27(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective: The effect of whole body irradiation (WBI) on B7-1 and B7-2 express ion in peritoneal macrophages in mice was observed.Methods:Immunohistochemistry (ABC method) was used. Results: The upregulation of B7-2 expression induced by WBI X-rays appeared ea r lier than that of B7-1.The study on the dose-effect relationship showed that t he ex pression of both B7-1 and B7-2 reached its peak at 0.075 Gy after WBI X-rays. Th e doses inducing a second peak of B7-1 and B7-2 upregulation were higher in th e case of WBI in comparison with in vitro irradiation. Conclusion: The results suggested that the upregulation of expression of B7 mole cules after irradiation might be an important factor involved in the enhancing e ffect of low dose radiation on immunity.
