EFFECT OF INDUCING DIFFERENATION OF ALL TRANS RETINOIC ACID ON IMMUNITY OF PATIENTS WITH GASTRIC CARCINOMA
- VernacularTitle:全反式维甲酸诱导分化治疗对胃癌患者免疫功能的影响
- Author:
Chengliang HUANG
;
Houdong LIU
- Publication Type:Journal Article
- From:
Chinese Journal of Bases and Clinics in General Surgery
2001;8(3):166-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of inducing differenation of all trans retinoic acid (ATRA) on immunologic function of patients with gastric cancer. Methods T-lymphocyte subsets(T-Ls) and interleukin-2 receptor(sIL-2R) of 56 patients with gastric cancer after treatment of ATRA were studied. Results In radical gastric cancer resection group, the serum CD3,CD4 and CD4/CD8 rate were higher and sIL-2R were lower than those in the control group, after treatment of ATRA, CD3,CD4 and CD4/CD8 rate and sIL-2R were as high as those in the control group. In the non-operative or palliative gastric resection group, CD3,CD4 and CD4/CD8 rates were increased markedly and the serum sIL-2R was decreased significantly than those in the control group. Conclusion ATRA inducing differenation can improve the immunity of the patients with gastric cancer.
