Relationship between the advanced glycation end products content and expressions of RAGE,ICAM-1 in vascular tissue of diabetic rats
- VernacularTitle:糖尿病大鼠血管糖基化终产物含量与其受体和ICAM-1表达的关系
- Author:
Jianwei ZHANG
;
Renyu SUN
- Publication Type:Journal Article
- From:
Basic & Clinical Medicine
2001;21(2):131-135
- CountryChina
- Language:Chinese
-
Abstract:
In this study,the relationship between the advanced glycation end products(AGEs) and the expressions of receptor for AGEs(RAGE),intercellular cell adhesion molecule-1(ICAM-1) was investigated.The diabetic rat model was reconstructed and the fluorescence method,RT-PCR and in-situ hybridization techniques were used to detect AGEs content and the expressions of RAGE and ICAM-1 gene in the aorta and cardiac tissues.The results showed that AGEs content in aortic and cardiac tissues increased(P＜0.01) in diabetic rats; The expressions of RAGE and ICAM-1 enhanced (P＜0.05～0.01) and were positively correlated with the quantity of AGEs accumulation(P＜0.01) in the aorta and cardiac tissue.These parameters change in the diabetic rats can be improved with aminoglumine(AG) treatment.Suggesting that AGEs might induce RAGE and ICAM-1 expression.It's postulated that AGEs binding to RAGE play an important role to result in diabetic endothelial cells dysfunction and lesion.
