EFFECTS OF CORTICOTROPIN RELEASING FACTOR ON LEARNING AND MEMORY IN THE NUCLEUS BASALIS OF MEYNERT IN RATS
- VernacularTitle:促肾上腺皮质激素释放因子在Meynert基底核中对大鼠学习记忆的影响
- Author:
Boning YANG
;
Guohe TAN
;
Li WEI
;
Ling LAN
- Publication Type:Journal Article
- Keywords:
corticotropin releasing factor;
spatial learning;
memory;
Morris water maze;
nucleus basalis of Meynert;
rat
- From:
Chinese Journal of Neuroanatomy
2005;21(5):503-506
- CountryChina
- Language:Chinese
-
Abstract:
The present study was performed to explore the role of corticotropin releasing factor (CRF) in the nucleus basalis of Meynert (NBM) in spatial learning and memory of rats. The latency, distance and swimming path to find the platform were measured by Morris water maze after intra-NBM injections of 0, 0.01, 0.1 and 0.4 nmol of CRF. Intra-NBM injections of 0.1 or 0.4 nmol of CRF induced significant increase of the latency for spatial learning and memory, and there were no significant changes in the swimming speed in Morris water maze test. The results suggest that CRF plays an inhibitory role in spatial learning and memory consolidation in the NBM of rats.
