Functional structure of γ-aminobutyric acid A receptor and depression, anxiety and epilepsy-related study
- VernacularTitle:γ-氨基丁酸A受体功能性结构与抑郁、焦虑及癫痫相关的研究
- Author:
Ruihua ZHANG
;
Liqin LI
;
Huifang WANG
;
Yanjun LI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2005;9(12):254-256
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: Because A type γ-aminobutyric acid (GABAA) receptor is widely used in clinical medicine, the receptor related drugs and relationship between structures and functions of GABAA receptor have been discussed according to the study at home and abroad.DATA SOURCES: Literatures related to GABAA receptor were searched from Medline and Elesiver science database by a computer, key word is "GABAA or GABAA benzodiazepine", and the language was restricted in English. And simultaneously, they were searched from CNKI database with the word-GABAAin Chinese. Time of search is January 1994 to August 2004.STUDY SELECTION: First trial for data, literatures related to GABAA receptor structures and pharmacological functions was selected, and then looking for full text. Functions or activities dissertated in literatures without relation to central nervous system and clinical therapy were excluded.DATA EXTRACTION: Thirty-six pieces of literatures that are related to GABAA receptor structures and functions were found, among which 24 pieces were excluded, 16 pieces were repeated and 8 pieces were Meta analysis study.DATA SYNTHESIS:There are 12 pieces of literatures measuring up in which receptor structures, functions and pharmacological functions were studied. Four kinds of drugs including sedative-diazepam, inhibitor-barbiturate, spasmogen-picxition and neuroactivesteoid act on this receptor.CONCLUSION: To study thoroughly the function of GABAA receptor subunits could provide techniques and approaches for screening the receptor subunit related anti-epilepsy drugs
