Daidzein and Genistein produced by a marine Micromonospora carbonacea FIM 02-635
- VernacularTitle:海洋碳样小单孢菌产生的大豆黄素和染料木素
- Author:
Hong JIANG
;
Yuanrong CHENG
;
Wei ZHENG
- Publication Type:Journal Article
- Keywords:
Micromonospora;
immunosuppressive;
isoflavones
- From:
Chinese Journal of Marine Drugs
2007;26(1):8-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the active secondary metabolites from marine microorganism FIM02-635. Methods The producing strain was identified by taxonomical and phylogenetic studies. Two compounds FW635I1 and FW635I2 with immunosuppressive activities were extracted by organic solvents from the culture broth and purified by silica gel column chromatography and high speed counter current chromatography. The structures of the two compounds were determined by physico-chemical properties and spectral analyses,the biological activities were assayed in vitro. Results and Conclusion The producing strain was named as Micromonospora carbonacea FIM 02-635. Two compounds FW635I1 and FW635I2 were determined to be isoflavone Daidzein and Genistein, respectively, showed immunosuppressive and antitumor activities, but not antimicrobial activities.
