Interaction of SNP in non-coding region between estrogen receptor alpha gene and brain-derived neurotrophic factor (BDNF) gene in late-onset Alzheimer's disease in southern Chinese Han population
- VernacularTitle:阿尔茨海默病脑源性神经营养因子和雌激素α受体基因的交互作用
- Author:
Yuping NING
;
Le HOU
;
Muni TANG
;
Yan TAN
;
Kangguang LIN
;
Haishan SHI
- Publication Type:Journal Article
- Keywords:
Late-onset Alzheimer's disease Brain-Derived neurotrophic factor Estrogen receptor alpha(Erα)Gene Interaction
- From:
Chinese Journal of Nervous and Mental Diseases
2009;35(12):717-721
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the interaction of BDNF gene C270T polymorphism and estrogen receptor alpha (ERα)gene Xba Ⅰ loci and Pvu Ⅱ loci polymorphism in late-onset Alzheimer's disease(LOAD)pathogenesis in southern Chinese Han population.Methods BNDF gene C270T locus,ERα gene Xba Ⅰ site and Pvu Ⅱ site polymorphisms were examined in 203 LOAD patients and normal controls using PCR-RFLP technique.Results There was an interaction be-tween BDNF gene and ERα gene,and BDNF gene C270T locus CC genotype and the ERa gene Xba Ⅰ locus xx genotype increased the LOAD incidance risk(OR=2.38,95%CI:1.02～5.53).Conclusions BDNF gene and ERα gene are in-teracted each other in the pathogenesis of LOAD.Patients carrying both BDNF gene C270T locus CC genotype and the ERα gene Xba Ⅰ locus xx genotypes might have an increased risk for LOAD.
