Effect of Rapamycin Eluting Stent for Inhibition of Neointimal Hyperplasia in Diabetic Porcine Model
10.3969/j.issn.1000-3614.2009.03.008
- VernacularTitle:雷帕霉素药物洗脱支架对糖尿病小型猪冠状动脉支架置入后内膜增生的影响
- Author:
Qi ZHANG
;
Lin LU
;
Lijin PU
;
Ruiyan ZHANG
;
Jian HU
;
Zhenkun YANG
;
Xian ZHENG
;
Aifang ZHENG
;
Weifeng SHENG
- Publication Type:Journal Article
- Keywords:
Coronary artery;
Diabetes;
Stent;
Rapamycin;
Restenosis
- From:Chinese Circulation Journal
2009;24(3):185-188
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of rapamycin eluting coronary stent for inhibition of neointimal hyperplasia in diabetic porcine model.Methods:There were two groups in this study. Diabetic group, n=12, diabetic porcine model was established by a single dose of streptozotocin, and rapamycin eluting coronary stents were randomly implanted into 2 of the major epicardial coronary arteries. Control group, n=12, with non-diabetic porcine. The degree of neointimal hyperplasia evaluated by coronary angiography, intravascular ultrasound (IVUS) and histopathology were compared between two groups respectively at 6 months of the event. Results:The distribution of vessels received stents, reference vessel diameters and post-procedural minimal luminal diameter were comparable between two groups. All animals received angiographic follow-up at 6 months of time. In Diabetic group, the degree of stent stenosis (35.6%±9.2% vs. 7.9%±3.1%,P<0.001), late lumen loss (0.32±0.09 mm vs. 0.09±0.04 mm,P<0.001), the thickness of neointima by IVUS examination (0.35±0.12 mm vs. 0.11±0.08 mm,P<0.05) and area stenosis by IVUS (1.29±0.51 mm~2 vs. 0.26±0.11 mm~2, P<0.001); and histopathological examination (1.24±0.76 mm~2 vs. 0.19±0.08mm~2, P<0.05) were significantly higher than those in Control group. Conclusion: The neointimal hyperplasia after rapamycin eluting stent implantation was significantly severe in the diabetic porcine models than those in non-diabetic ones.
