The protection of isoflavones on myocardium in myocardial infarction mouse
- VernacularTitle:葛花异黄酮对急性心肌梗死小鼠心肌的保护作用
- Author:
Jinfeng WANG
;
Huaben BO
;
Xiangying MENG
;
Yin WU
;
Yongli BAO
;
Yuxin LI
- Publication Type:Journal Article
- Keywords:
isoflavone;
acute myocardial infarction;
β-ARK_1;
SOD;
MDA;
RT-PCR
- From:
Chinese Pharmacological Bulletin
2010;26(1):59-62
- CountryChina
- Language:Chinese
-
Abstract:
Aim By establishing mouse acute myocardial infarction model,to observe the protection of isoflavones on ischemic myocardium and research the mechanism.Methods Mouse acute myocardial infarction model was established by ligating the left anterior descending(LAD)coronary artery.Danshen was used as the positive control.The effect of isoflavones on myocardial infarct area,serum myocardium creatase and serum levels of SOD and MDA was observed.By Real Time PCR,it was found that isoflavones could affect the expression of β-adrenergic receptor kinase(β-ARK_1).Results Isflovones could obviously reduce the myocardial infarct area and lower the levels of serum myocardial creatase and MDA.It could downregulate the expression of β-ARK_1 as the doses are increased.Conclusions Isoflavones can protect the myocardium of acute myocardial infarction mouse.The mechanism is related to the reduction of the oxidative damage,and the downregulation of the expression of β-ARK_1.
