Myostatin Gene Expression Level in the Soleus Muscle of Tail-Suspended Rats
- VernacularTitle:尾悬吊大鼠比目鱼肌'肌肉生长抑制素'基因的表达水平
- Author:
Qingsheng HUANG
;
Qi LI
;
Mingjie ZHANG
- Publication Type:Journal Article
- Keywords:
Myostatin;
Tail-suspended rat;
Weightless;
Soleus muscle
- From:
Acta Laboratorium Animalis Scientia Sinica
2010;18(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of tail-suspending on myostatin(MSTN)expression in the soleus muscle of rats.Methods The MSTN mRNA levels in soleus muscle of tail-suspended and normal control rats were measured and compared.Results The MSTN mRNA in soleus muscle of tail-suspended rats was 2.2 times(hind limb unloading for 14 days)and 3.5 times(hind limb unloading for 30 days) higher than that in normal control rats (P<0.05).The relative wet weight of the soleus muscle in tail-suspended rats was decreased by 11%(unloading 14 days)and 1 9%(unloading 30 days),respectively,compared with that in normal control rats.Conclusion The expression of MSTN mRNA is elevated in the soleus muscle of tail-suspended rats,probably due to atrophy of the soleus muscle.
