Association of Polymorphisms in Atrial and Brain Natriuretic Peptide Gene with Essential Hypertension
10.3870/j.issn.1672-0741.2010.01.004
- VernacularTitle:心房利尿钠肽和脑利尿钠肽基因多态性与原发性高血压病的关联性研究
- Author:
Changjun TIAN
;
Longxian CHENG
- Publication Type:Journal Article
- Keywords:
essential hypertension;
atrial natriuretic peptide;
brain natriuretic peptide;
gene polymorphism
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2010;39(1):13-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations of atrial natriuretic peptide(ANP)rs5065 and brain natriuretic peptide(BNP)rs198389 gene polymorphisms with human essential hypertension(EH).Methods A total of 976 patients with EH and 976 age-and sex-frequency matched normotensive(NT)control subjects were collected.The ANP rs5065 and BNP rs198389 polymorphisms were genotyped by real-time quantitative polymerase chain reaction(real-time Q-PCR)method--Taqman probe.Results There was significant difference in frequency distribution of AA and AG+GG genotypes,A and G allele of BNP rs198389 between the EH and NT groups(P＜0.05).The frequency of AG+GG genotype and G allele was significantly higher in the EH group(30.5% and 17.3%)than in the NT group(26.1% and 14.1%).There was no difference in distribution of ANP rs5065 polymorphism between EH and NT groups(P＞0.05).By unconditional Logistic regression analysis of rs198389,before adjusted for the EH risk factors,AG+GG genotype presented a significantly higher risk of EH(P=0.04)than AA genotype,and this risk was still significant after adjusted for the EH risk factors(P=0.02).G allele had more significantly increased risk of EH than A allele(P=0.04).However,there was no significant difference before or after adjusted for the EH risk factors in unconditional Logistic regression analysis of rs198389.Conclusion rs198389 polymorphisms of BNP gene may be associated with EH,but rs5065 polymorphisms of ANP gene may be not associated with EH.
