Neuroprotective Effects of Amiloride
- VernacularTitle:阿米洛利的神经保护作用
- Author:
Kang YE
;
Guanglai LI
- Publication Type:Journal Article
- Keywords:
amiloride;
neuroprotection;
cerebral ischemia
- From:
International Journal of Cerebrovascular Diseases
2008;16(6):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Amiloride is an epithelial Na+ channel(EnaC)blocker.As a potassium-sparing diuretic,it has been used in clinical practice for decades of years.Studies have shown that many ion channels were semitive to amiloride in the central nervous system,such as acid-sensitive ion channel(ASIC)and Na+/H+ exchanger.These channels have important physiological functions,and paticipate in pathological processes such as cerebral ischemia and tissue acidosis.It has demonstrated that amailoride reduces the effects of ischemia-and acid-mediated neuronal injury by blocking these channels,which may become a novel neuroprotective agent for the treatment of cerebral ischemia.
