Clinical significance of combined determination of the changes of serum insulin-like growth factor-Ⅱ,carbohydrate antigen 19-9 and alpha fetoprotein levels after intervention and percutaneons ethanol injection therapy in patients with primary hepatic cancer
- VernacularTitle:原发性肝癌患者介入合并无水乙醇注射治疗前后血清IGF-Ⅱ、CA19-9和AFP联检的疗效观察
- Author:
Zhiling QIAN
;
Shichang CUI
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Insulin-like growth factor Ⅱ;
Antigens,tumor-associated,carbohydrate
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(27):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of changes of serum insulin-like growth factor-Ⅱ(IGF-Ⅱ),carbohydrate antigen 19-9(CA19-9)and alpha fetoprotein(AFP)levels after intervention and percutaneous ethanol injection therapy in patients with primary hepatic cancer.Methods Serum levels of IGF-Ⅱ,CA19-9 and AFP(with RIA)were repeatedly determined in 57 patients with primary hepatic cancer before intervention therapy,1 month after intervention and percutaneous ethanol injection therapy and 6 months after intervention and percutaneous ethanol injection therapy as well as in 42 controls.Results Before intervention therapy,serum leveh of IGF-Ⅱ,CA19-9 and AFP in the patients were significantly higher than those in the controls(P＜0.01).One month after intervention and percutaneous ethanol injection therapy,all the serum levels were near to normal.Six months later,the levels in the patients without recurrence remained normal.However,the levels in the 10 patients with recurrence returned to those before intervention therapy again.Conclusion Changes of serum IGF-Ⅱ,CA19-9 and AFP levels are closely related to the tumor burden and may reflect the presence of recurrence.
