Changing of dihydrotestosterone In prostate after treating by epristeride
- VernacularTitle:5α还原酶抑制剂对人前列腺组织中双氢睾酮的影响
- Author:
Haihan WU
;
Zhiling WENG
;
Chengli LI
- Publication Type:Journal Article
- Keywords:
Benign prostatic hyperplasia;
Dihydrotestosterone;
Epristeride;
Finasteride
- From:Chinese Journal of Urology
2008;29(z1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effect of the concentration of dihydrotestostemne(DHT)in prostatic tissue treating by 5a-reductase inhibitors.Methods One hundred and twenty-one pros-tatic samples were selected:group A1(18 patients treating by epristeride for 1 month),group A2(22patients treating by epristeride for 3 months),group B1(23 patients treating by finasteride for 1 month),group B2(21 patients treating by finasteride for 3 months),group C(25 patients non-treating by 5α-reductase inhibitors),group D(12 samples of prostate from body).The concentration of DHT was measured by radio-immunity,Results The concentration of DHT in prostate declined after treating by epristeride 1 month and 3 months(66.21%and 70.60%,P＜0.05).The decline of the concentration of DHT in prostate after treating by epristeride 1 month was larger than 3 months(P＜0.05).The concentration of DHT in prostate declined after treating by finasteride 1 month and 3 months.There Was no signiificant difference of the concentration of DHT in prostate after treating by finasteride 1 month and 3 months.Conclusions The concentration of DHT in prostate can be declined after treating by epristeride and finasteride.The decline of the concentration of DHT is consistent aftertrealring by epristeride.The decline of the concentration of DHT is considerable between epristeride and finasteride.
