Differences of tacrolimus' dosage and concentration of individuals in morning periods after renal transplantation
10.3760/cma.j.issn.1000-6702.2009.03.003
- VernacularTitle:肾移植受者术后早期他克莫司用药剂量及浓度个体差异的研究
- Author:
Lixin YU
;
Yanbin WANG
;
Lulu XIAO
;
Shaojie FU
;
Junsheng YE
;
Qiang LI
;
Yibin WANG
- Publication Type:Journal Article
- Keywords:
Plasma concentration;
Tacrolimus;
CYP3A5;
Multidrug resistance gene 1;
Gene polymorphism
- From:
Chinese Journal of Urology
2009;30(3):152-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influential factors of tacrolimus'dosage and concentration differences between individuals in morning periods after renal transplantation.Methods The clinical data consisted of 118 receptors in morning periods after renal transplantation,whose immune suppressions were tacrolimus,mycophenolate and hormone.At 3,7,14 and 30 d after operation,all the receptors'weight,dosage of tacrolimus,dosage of hormone,diarrhea,blood fat,liver function,renal function,albumn and erythrocrit were recorded respectively,and at the same time their concentrations of tacrolimus and genetic polymorphisms of CYP3A5,MDRl 3435,MDR1 2677 and MDRl 1236 weredetected.Multiple linear regressions were performed.Results The fitting degrees of stepwise regression equations were low.At 3,7,14 and 30 d after operation,the adjusted R2was 0.284,0.267,0.417 and 0.324,respectively.From the aspect of pharmacogenomics,the main factors rela-ted to the differences of tacrolimus'dosage and concentration included MDR1 2677,MDRl 1236 and MDR13435,which varied intensively.Age,albumn,renal function,blood fat and liver function were important factors too.Conclusions The main reasons of the differences of tacrolimus'dosage and concentration between individuals in morning periods after renal transplantation are medicines and changes of internal environment after operation.The genetic polymorphisms of MDR1,age,albumn,renal runetion.blood fat and liver function are important factors too.
