Effect of Berberine on HMGB1 Release from Macrophages and its Mechanism
10.3760/cma.j.issn. 1673-4246.2009.02.002
- VernacularTitle:小檗碱抑制巨噬细胞HMGB1释放及机理研究
- Author:
Guoqian CHEN
;
Tingting WANG
;
Zhigang HU
;
Chunxin WANG
;
Ming XU
- Publication Type:Journal Article
- Keywords:
HMGB1;
Berberine;
Macrophage
- From:
International Journal of Traditional Chinese Medicine
2009;31(2):103-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of berberine on extracellular release of high mobility group box 1 (HMGB1) and its mechanism. Methods After LPS was activated by different concentration of berberine, the release of HMGB 1 and TNF-a, and expression of HMGB 1 mRNA in cultured mouse peritoneal macrophages was investigated. Results Berberine markedly suppressed the release of HMGB 1 and expression of HMGB 1 mRNA from LPS-stimulated macrophages (P<0.05). While the release ofTNF-a was't significantly affected. Conclusion Berberine suppressed extracellular release of HMGB 1 by decreasing expression of HMGB 1 mRNA.
