Intervention Effect of Berberine on the Level of Serum Lipids, OX-LDL and Vascular Intimal Injury in Diet-induced Hyperlipidemic and Chlamydia Pneumoniae-infected Mice
10.3760/cma.j.issn.1673-4246.2009.03.002
- VernacularTitle:黄连素对CPn感染高脂饮食小鼠血脂、OX-LDL及血管内膜损伤的干预作用
- Author:
Song WANG
;
Wei WU
;
Yude LIU
;
Yanshou HUANG
- Publication Type:Journal Article
- Keywords:
Chlamydia pneumoniae;
Berbefine;
Serum lipid;
OX-LDL
- From:International Journal of Traditional Chinese Medicine
2009;31(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the variation of the level of lipids, OX-LDL and vascular intimal injury in diet-induced hyperlipidemic and chronic Cpn-infected mice and the interventional functions of berberine. Methods C57BL/6J mice were divided randomly into 6 groups: Berl group, Ber2 group, azithromycin group, atorvastain group, cholesterol + Cpn group, and normal group. Mice were inoculated intranasally with Cpn for three times, every 2 weeks over a 6-week period and feeding with high cholesterol diet. Berl group was administrated with berberine at the beginning of CPn infecting, while ber2 group, azithromycin group and atorvastain group were administrated with the drug after the 3rd CPn infecting. The serum index, HE dye of the aortas and electron microscopic examination were observed. Results Lipids disorder, increased level of OX-LDL and vascular intimal injury were found. The level ofTC, LDL, TG OX-LDL in Bet group, azithromycin group, and atorvastain group declined in different extent. Conclusion Berberine has effects of regulating lipids disorder, OX-LDL and protecting vascular intima of diet-induced hyperlipidemic and chronic Cpn-infected mice.
