Expression of Hsp22 and VEGF after brain I/R injury in gerbils and its neuroprotective effects
- VernacularTitle:沙鼠脑缺血再灌注损伤后Hsp22和VEGF表达的变化及神经保护作用
- Author:
Xiang YU
;
Xiaoping GAO
;
Yao ZHANG
;
Zhipin HU
- Publication Type:Journal Article
- Keywords:
Brain ischemia/ME;
Reperfusion injury/PC;
Heat-shock proteins/ME;
Vascular endothelial growth factors/ME
- From:
Journal of Chinese Physician
2009;11(6):750-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this study we investigated the expression and protective mechanisms of Hsp22 and VEGF in brain tissue following cerebral ischemic reperfusion in gerbils and whether they are correlative. Method Forty five gerbils were randomly divided into there groups: Normal Group (n =5) ,Sham-operated Group and Ischemia-Reperfusion Group (I/R). Sham-operated Group and I/R Group were divided into four subgroups (each group has five animals) : 6 hours group, lday group, 3days group, 7days group. Histological analysis of tissue injury was carried out by staining with haematoxylin and eosin haematoxylin and eosin (HE). Result The tissues of normal group and sham-operated group was integrated, but that of I/R were changed with gliocyte hyperplasia and hypertrophia, interstitial edema, cellular edema, gliocyte and neuron edema , neuron necrosis. The data presented here provided a positive correlation between expression of Hsp22 and VEGF. Conelusions There was a positive correlation between expression of Hsp22 and VEGF after gerbils brain I/R injury.
