Mechanism of advanced glycation end products-stimulated phosphorylation of ERM protein in human umbilical vein endothelial cells
10.3760/cma.j.issn.1000-6699.2010.01.006
- VernacularTitle:晚期糖基化终产物诱导人脐静脉内皮细胞ERM蛋白磷酸化的机制
- Author:
Zhanhua WANG
;
Xiaohua GUO
;
Bo CHEN
;
Qiang LI
;
Jiping WANG
;
Ping ZHU
;
Lingjun WANG
;
Wei WU
;
Qiaobing HUANG
- Publication Type:Journal Article
- Keywords:
Glycation end products;
advanced;
Ezrin/radixin/moesin;
Mitogen-activated protein kinase;
Rho kinase
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(1):19-21
- CountryChina
- Language:Chinese
-
Abstract:
The effects of advanced glycation end products(AGE)on phosphorylation of ezrin/radixin/ moesin(ERM)protein in human umbilical vein endothelial ceils were detected by immunofluorescence cytochemistry and its mechanism was explored.AGE stimulated the phosphorylation of ERM protein in dose-and time-dependent manners(all P<0.05),which was involved in AGE receptor,Rho kinase,and p38 mitogen-activated protein kinase pathways.
