Induction of apoptosis and cell cycle arrest in human endometrial cancer cells by adiponectin
10.3760/cma.j.issn.1000-6699.2010.02.017
- VernacularTitle:脂联素对子宫内膜癌细胞生长抑制和细胞凋亡的影响
- Author:
Li CONG
;
Wei WANG
;
Qiang LI
;
Zijian ZHAO
;
Jinchao ZHANG
- Publication Type:Journal Article
- Keywords:
Adiponectin;
Endometrial carcinoma;
Apoptosis;
AMP-activated protein kinases
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(2):148-149
- CountryChina
- Language:Chinese
-
Abstract:
Two human endometrial carcinoma cell lines, HEC-1-A and RL95-2, were treated with adiponectin,and then changes of cell count, apoptosis and cell cycle arrest were measured. The expression of phospho-AMPK(Thr172) and AMPK was determined by Western Blot. The results showed that adiponectin may exert direct anti-proliferative effects on HEC-1-A and RL95-2 cells by inducing cell cycle arrest and apoptosis, which may be mediated by AMPK pathway.
