Corticotropin-releasing factor and hypoxic-ischemic brain damage
10.3760/cma,j.issn.1673-4912.2010.01.032
- VernacularTitle:促肾上腺皮质激素释放因子与缺氧缺血性脑损伤
- Author:
Jing DONG
;
Chao CHEN
;
Yimin ZHU
- Publication Type:Journal Article
- Keywords:
Corticotropin-releasing factor(CRF);
Hypoxia;
Hypoxia-ischemia brain damage;
Infant,newborn
- From:Chinese Pediatric Emergency Medicine
2010;17(1):71-74
- CountryChina
- Language:Chinese
-
Abstract:
Corticotropin-releasing factor(CRF)is one neuroendocrine peptide which is closely related with the stress.It has been proved that any stress can lead to the person and animal's blood CRF level increasing,and high-level CRF urges the hypothalamic neuron calcium ion inflow.Newborn pediatricians pay more attention to whether blood CRF level can act as one director of assessing severity of newborn hypoxic-schemic brain damage.This article reviews the CRF and it's acceptors,CRF secretion,CRF physiological action and it's adjustment,and hypoxia-ischemia stress and CRF,in order to provide the theory basis for reviewing the severity of hypoxic-schemic brain damage in neonates.
