Corticotropin-releasing factor and hypoxic-ischemic brain damage

VernacularTitle:促肾上腺皮质激素释放因子与缺氧缺血性脑损伤
Author: Jing DONG ; Chao CHEN ; Yimin ZHU
Publication Type:Journal Article
Keywords: Corticotropin-releasing factor(CRF); Hypoxia; Hypoxia-ischemia brain damage; Infant,newborn
From: Chinese Pediatric Emergency Medicine 2010;17(1):71-74
CountryChina
Language:Chinese
Abstract: Corticotropin-releasing factor(CRF)is one neuroendocrine peptide which is closely related with the stress.It has been proved that any stress can lead to the person and animal's blood CRF level increasing,and high-level CRF urges the hypothalamic neuron calcium ion inflow.Newborn pediatricians pay more attention to whether blood CRF level can act as one director of assessing severity of newborn hypoxic-schemic brain damage.This article reviews the CRF and it's acceptors,CRF secretion,CRF physiological action and it's adjustment,and hypoxia-ischemia stress and CRF,in order to provide the theory basis for reviewing the severity of hypoxic-schemic brain damage in neonates.