Construction of a nomogram predicting the risk of regional lymph node metastases in penile sqnamous cell carcinoma
10.3760/cma.j.issn.1000-6702.2010.03.017
- VernacularTitle:建立预测阴茎鳞状细胞癌区域淋巴结转移风险的列线图
- Author:
Yao ZHU
;
Shilin ZHANG
;
Dingwei YE
;
Xudong YAO
;
Bo DAI
;
Hailiang ZHANG
;
Yijun SHEN
- Publication Type:Journal Article
- Keywords:
Penile neoplasms;
Lymphatic metastasis;
Biological markers;
Nomograms
- From:
Chinese Journal of Urology
2010;31(3):207-210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To construct and evaluate a nomogram for predicting the risk of regional lymph node metastases according to pathological features of the primary penile squamous cell carcinoma. Methods The clinical and pathological data of 73 patients who had undergone partial/radical penectomy and ilio/inguinal lymphadenectomy for squamous cell carcinoma of the penis from 1990 to 2005 were retrospectively collected. The expressions of molecular markers (p53, Ki-67, E-cadherin and MMP-9) were determined by immunohistochemistry. A logistic regression model was used to construct the nomogram. Results Tumor grade, the expression level of p53 and lymphovascular invasion were independent prognostic factors of regional lymph node involvement (P<0. 05). The nomogram predicting the risk of metastatic lymph node involvement showed a good concordance index (0. 92) and good calibration. Conclusions Based on the pathological findings of primary tumor, a nomogram to predict the probability of regional lymph node involvement in penile squamous cell carcinoma patients is constructed. This statistical tool is not only helpful in judging individualizing tumor risk, but also in facilitating patients communication in treatment options.
