The neuroprotection of edaravone and GM1 on the rat model of parkinson disease
10.3760/cma.j.issn.1674-6554.2010.04.009
- VernacularTitle:依达拉奉、神经节苷酯对帕金森病模型大鼠的神经保护作用
- Author:
Yan LI
;
Shenggang SUN
;
Qingsheng KONG
;
Jinbo SUN
;
Yanxin ZHAO
;
Nan ZHOU
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
Cell apoptosis;
Rotate action;
GM1;
Edaravone
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(4):317-318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protect effects of Edaravone(Ed)and GM1 on the rat model of parkinson disease(PD).Methods To establish the unilateral PD rat model,6-OHDA was injected at two points of right substantial nigra pars compacta(SNC),ventral tegmental area(VTA),then the old rats were randomly divided into normal,NS,PD,PD + GMI,PD + Ed,FD + GM1 + Ed six groups.14d later,a rotational test induced by apomorphine was performed to determine the successful ratio.Cell apoptosis in SNC of rats were examined by TUNEL methods.Results Normal and NS groups unappeared rotate action by APO,and have no cell apoptosis in SNC.The other groups all appear rotate action(＞7 r/min)by APO,rotate action were in following gradation:PD +GM1 + Ed group(8.0±0.3)＜PD + Ed group(12.0±0.6)＜PD + GM1 group(17.0±1.0)＜PD group(23.0±1.3)(P＜0.01);and cell apoptosis in SNC were in following gradation:PD + GM1 + Ed group(27.63±2.38)＜PD + Ed group(38.42±3.54)＜PD + GM1 group(49.36±3.12)＜PD group(62.61±4.03)(P＜0.01).Conclusion 6-OHDA could induce change of action of rat and cell apoptosis in SNC.GM1,Ed reduce significantly the effect induced by 6-OHDA.GM1 combining with Ed have the best effects.
