Neuroprotective mechanisms of histone deacetylase inhibitors in ischemic stroke
10.3760/cma.j.issn.1673-4165.2010.005.008
- VernacularTitle:组蛋白去乙酰化酶抑制剂在缺血性卒中中的神经保护机制
- Author:
Lijuan HAN
;
Yun XU
- Publication Type:Journal Article
- Keywords:
Histone deacetylase inhibitors;
Histone deacetylases;
Stroke;
Brain ischemia;
Neuroprotective Agents;
Inflammation;
Apoptosis
- From:International Journal of Cerebrovascular Diseases
2010;18(5):358-362
- CountryChina
- Language:Chinese
-
Abstract:
Histone deacetylases (HDACs) catalyze the deacetylation of histone and nonhistone proteins. They play important roles in regulating chromatin remodeling and gene transcription,and that aberrant chromatin remodeling and transcriptional dysregulation are associated with many neurodegenerative diseases. Preclinical studies have suggested that histone deacetylases inhibitors (HDACIs) can target diverse pathophysiologies of ischemic stroke,not only reduce neuronal damage and infarct volume,but also promote the neuronal plasticity and functional recovery after ischemia. This article mainly reviews the neuroprotective mechanisms of HDACIs in ischemic stroke.
