Study on the mechanism of developing hyperglycemia in monosodium glutamate induced obese mice with insulin resistance

VernacularTitle:谷氨酸钠诱导的肥胖胰岛素抵抗小鼠血糖升高机制研究
Author: Caina LI ; Ning SHEN ; Shuainan LIU ; Quan LIU ; Yi HUAN ; Sujuan SUN ; Zhufang SHEN
Publication Type:Journal Article
Keywords: Monosodium glutamate; Hyperglycemia; Insulin resistance; Obesity; Glucagon
From: Chinese Journal of Endocrinology and Metabolism 2010;26(9):799-802
CountryChina
Language:Chinese
Abstract: The blood insulin levels of insulin resistant monosodium glutamate induced mice (IR-MSG)and hyperglycemic monosodium glutamate mice (HG-MSG) markedly increased ( P<0. 01 ), and the weight index of pancreas significantly decreased ( P<0. 01 ), accompanied with overt inflammatory infiltration in the exocrine part of pancreas. Besides, insulin and glucagon in the islets also markedly increased with irregular distribution ( P<0.01 ). Compared to IR-MSG mice, HG-MSG mice showed overt hyperglycemia and much lower blood insulin. Moreover, the weight of pancreas in HG-MSG mice markedly decreased ( P < 0.05 ), along with less insulin and more glucagon in the lessened and contracted islets, suggesting that the injury of pancreas in the HGMSG mice might be more severe, which may result in hyperglycemia.