Diabetes and cancer
10.3760/cma.j.issn.1673-422X.2010.10.008
- VernacularTitle:糖尿病与肿瘤
- Author:
Honghua TAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Neoplasms;
Hyperinsulinism;
Insulin-like growth factor Ⅰ
- From:
Journal of International Oncology
2010;37(10):742-745
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes and cancer, two heterogeneous multffactorial severe chronic diseases, are closely related. Epidemiological studies clearly indicate that diabetics have an increased risk and mortality of several cancers, including cancers of the pancreas, liver, breast, colorectum and urinary tract. Insulin is a growth factor with preeminent metabolic and mitogenic effects and functions at both receptor and post-receptor level during cancer development. As a result, hyperinsulinemia is the most likely cause of cancers among diabetic patients. However, anti-diabetic drugs, obesity, hyperglycemia, and increased oxidative stress may also contribute to the increased cancer risk among diabetics.
