Efficacy and safety of solifenacin in the treatment of overactive bladder
10.3760/cma.j.issn.1000-6702.2010.11.006
- VernacularTitle:索利那新治疗膀胱过度活动症的有效性及安全性分析
- Author:
Wansong GUO
;
Bo YANG
;
Xiangbo KONG
;
Chuize KONG
;
Zeshou GAO
;
Zhenhua LI
;
Yuanyuan WANG
;
Litao ZHAO
;
Zhiyong ZHANG
;
Wei WANG
;
Bo WU
;
Xudong LI
;
Hongge ZHOU
- Publication Type:Journal Article
- Keywords:
Overactive bladder;
Solifenacin;
Clinical trials
- From:
Chinese Journal of Urology
2010;31(11):745-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of solifenacin in patients with overactive bladder (OAB). Methods A multicenter clinical trial was conduced. 216 patients with OAB were enrolled. All the patients received solifenacin(5 mg once daily). With 5 weeks'treatment, all the patients recorded the diary and the adverse events as well. The symptoms of urgency, frequency, nocturia, urine volume, incontinence were evaluated. The results of the efficacy and safety were analyzed by using SPSS 13. 0. Results After 5 week treatments, all the index obviously improved(P<0.05). 187 cases (86.7%)were cured and 43 cases recovered normal voiding, 29 cases improved obviously. 11cases(5.0 %)reported adverse effect as dry mouth, dry eye. Conclusion Solifenacin could be the safe and effective drug in the treatment of OAB patients.
