Expression and clinical significance of c-kit and PCNA in renal cell carcinoma (RCC) subtypes
10.3760/cma.j.issn.1000-6702.2010.11.008
- VernacularTitle:不同肾癌亚型组织中c-kit与增殖细胞核抗原的表达及意义
- Author:
Xin YAO
;
Yanhui ZHANG
;
Lei DIAO
;
Qing YANG
;
Wei CUI
;
Jian DUO
;
Yanxue LIU
;
Suxiang LIU
- Publication Type:Journal Article
- Keywords:
Carcinoma renal cell;
Immunohistochemistry;
c-kit protein;
Proliferating cell nuclear antigen
- From:
Chinese Journal of Urology
2010;31(11):752-757
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of c-kit and analyze its relationship with proliferating cell nuclear antigen (PCNA) in RCC subtypes and its clinical progression. Methods Expression of c-kit protein was retrospectively studied with immunohistochemistry in paraffin sections from 137 cases of clear renal cell carcinoma (CCRCC), 82 papillary renal cell carcinoma (PRCC), 51 chromophobe renal cell carcinoma (ChRCC). Results The positive rate of c-kit in ChRCC was 94.1%(48/51), it was statistically higher than that in CCRCC (16. 1%, 22/137) and PRCC (28.1 %, 23/82)(P=0. 001 ). In ChRCC, the positive expression of c-kit was related with TNM stages. The positive expression of PCNA was related with the grade in CCRCC and PRCC. But there was no relationship between PCNA expression and grade of ChRCC. It also had the relationship with the metastasis in CCRCC. Conclusions The expression of c-kit in ChRCC is higher than in other subtype of RCC, and associated with tumor local progression. That makes c-kit as a helpful marker to discriminate different subtypes of kidney cancer.
