Effect of mulberry flavone on insulin receptor substrate expression in HepG2 cells with insulin resistance
10.3760/cma.j.issn.1008-6315.2010.11.003
- VernacularTitle:桑叶黄酮对胰岛素抵抗HepG2细胞胰岛素受体底物表达的影响
- Author:
Yanhui SU
;
Nannan ZHANG
;
Hongmei ZHU
;
Jiao YANG
;
Qiu CHEN
- Publication Type:Journal Article
- Keywords:
Mulberry flavone;
Insulin resistance;
HepG2 cells;
Insulin receptor substrate
- From:
Clinical Medicine of China
2010;26(11):1129-1131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the role of mulberry flavone on the expression of insulin receptor substrate(IRS)in HepG2 cells with insulin resistance, and to explore the possible molecular mechanism that mulberry flavone improves insulin resistance. Methods HepG2 cells were cultured to establish insulin-resistance cell model in high concentration of insulin, and then incubated with mulberry flavone. Effect of mulberry flavone on the HepG2 cell model of glucose incorporation rate was observed. Western blot was used to observe the variety of IRS protein expression. Results Mulberry flavone increased the glucose incorporation rate of (33. 9 ± 1.0)higher than that of Conclusions Mulberry flavone can improve insulin resistance. Furthermore, IRS protein expression increasing is the possible molecular mechanism that mulberry flavone improves insulin resistance.
